Promote a Culture of Safety: Revisiting the Safety Cross and Run Charts

Patient Safety has been a challenge for healthcare facilities worldwide. Ensuring the safety of the patient is the duty of each healthcare professional as emphasised in the Hippocratic oath, 'ldquo;above all, do no harm'rdquo;. Nurses in the healthcare team are pivotal in the provision of patient care. They spend more time with patients than others and are in direct communication with the patient and family, so they are better placed to mitigate harm. Hence nurses need to be vigilant, engaged and invested in patient safety and improvement in quality care. Nursing education and training too should serve as a platform for increased efforts in this direction and include opportunities for continued learning. Discussed in this paper are two simple measures such as '#39;safety cross and run charts'#39; that can be used to promote patient safety by recognising risks and preventing harm or adverse events.

Application of Westgard internal quality control frequency on-line calculator in general chemistry internal quality control / 中华检验医学杂志

Objective:An on-line calculator for calculating the frequency of internal quality control is recommended to select quality control procedures and appropriate run lengths for general chemistry in Beijing Tongren Hospital.Methods:The cumulative controlled coefficient of variations of 10 general chemical tests in the laboratory department of Beijing Tongren Hospital for 19 consecutive months were used as the imprecision. The mean value of absolute percentage difference between the quality control results and the target value of 15 batches of 10 tests in the external quality assessment (EQA) general chemistry in 2018 was used to estimate the Bias of each test. Use the allowable range of EQA target value of the National Center for Clinical Laboratories in 2018 to estimate the total allowable error (TEa) of each test. The data were input into the Westgard internal quality control frequency calculator, and 10 different candidate statistical quality control (SQC) procedures and corresponding run lengths were calculated online, including single rule and multiple rule, number of quality control concentration levels (or test projects) ranging from 1 to 4. The SQC program with relatively simple quality control rules and long run length was selected according to the actual situation of the laboratory.Results:The 1 3s, N=3 or 1 3s, N=2 rule could be adopted for ALP and CR, and the corresponding run length was 1000. TBIL and ALT projects can adopt 1 3s, N=3 or 1 3s, N=2 rule and its corresponding run length; UA can use multiple rules 1 3S/2 2S/R 4s/4 1s, N=4 (run length 395) or 1 3S/(2of3) 2S/R 4s/3 1s N=3 (run length 259); CHO, AST and AMY can adopt two multiple rules 1 3S/2 2S/R 4s/4 1s, N=4 or 1 3S/(2of3) 2S/R 4s/3 1s, N=3 and their corresponding run length. GGT project can adopt 1 3S/2 2S/R 4s/4 1S, N=4 rule (run length 50); The run length of 10 candidate quality control rules calculated by LDH was too short, the detection performance should be improved preferentially, and the quality control rules and corresponding run length were not recommended for the time being. Conclusion:The Westgard internal quality control frequency online calculator is easy to operate. Clinical laboratories can use this calculator to select SQC program and appropriate run length. It is recommended that laboratories adjust SQC program according to the current actual situation.

Design of internal quality control program for specific protein testing based on patient risk / 中华检验医学杂志

Objective:Patient risk-based statistical quality control (SQC) program was designed for 9 specific protein projects using Westgard sigma rules with run length.Methods:The cumulative coefficient of variation of immunoglobulin (Ig)G, IgA, IgM, C3, C4, rheumatoid factor (RF), antistreptolysin O (ASO), transferrin (TRF) and prealbumin (PA) from the laboratory department of Beijing Tongren Hospital between December 2018 to May 2019 were used as the estimated value of imprecision. The mean of the absolute value of the percentage difference of 10 batches in the laboratory, which was derived from the results of participating the external quality assessment (EQA), was used as the estimated value of bias. The National Center for Clinical Laboratories EQA evaluation criteria was used as an allowable total error (TEa), and the sigma value of each project (σ) was calculated. Westgard Sigma rule with run length was used to design appropriate SQC program for each project, including quality control rules, number of control measurements (N) and frequency of quality control.Results:The sigma value was larger than 6 for SQC procedure of IgG, IgA, IgM, C4 and TRF. SQC could be established with the use of 1 3s rule, number of control measurements (N)=2, number of runs (R)=1, and a run length of 1 000 patient samples. Combined with the average daily workload, internal quality control could be conducted once every 10 days for IgG, IgA, IgM and C4, every 50 days for TRF. The σ was 5.86 for C3, SQC program could be established with run length of 450 using 1 3S/2 2S/R 4s rule (N=2, R=1), combined with average daily workload, internal quality control could be conducted every 4.5 days. σ was between 3 and 4 for RF, ASO and PA. With the use of 1 3S/2 2S/R 4s/4 1s/6 X rule (N=6, R=1), SQC program with a run length of 45 and higher frequency internal quality control activities. Conclusion:It is feasible to use Westgard sigma rules with run length for the laboratories design of personalized risk-based SQC procedures, the method is very simple and intuitive. This tool is valued to be recommended to be actively applied by all clinical laboratories.

Discussion on problems and countermeasures of military medical radiation license management / 中国辐射卫生

@#Practice in military medical radiation license management in the new era of military reform have surfaced problems in military radiation protection, involving radiation protection management regulation, occupational health monitoring for radiation workers, inspection of radiation equipment and site protection, implementation of the “Three Synchronizations System” for construction, renovation, and extension projects of radiation facilities, as well as quality control for radiation protection and diagnosis and treatment. Efforts should be focused on radiation protection training, self-management of medical radiation institutions, supervision and regulation from medical radiation license management institutions, and joint coordination of relevant departments. Under new regulations and standards, creatively conducting medical radiation license management and running the army in accordance with the law in the new era of military reform are of great significance for standardizing military radiation protection and ensuring the healthy development of military medical radiation services.

Relationship between physical fitness and phase angle based on bioelectrical impedance analysis in 6-year-old children / 体力科学

Phase angle, calculated as the arc-tangent of the reactance-to-resistance ratio in bioelectrical impedance analysis, represents skeletal muscle quality, and is suggested to be an indicator of sports ability and physical fitness. However, it is unclear whether phase angle is related to physical fitness in early childhood in Japanese subjects. The purpose of this study was to examine the cross-sectional relationship between physical fitness and bioelectrical impedance analysis-based phase angle in 6-year-old Japanese children. The subjects were 85 kindergarten students who participated in a physical fitness test and body composition assessment in 2017, 2018 or 2019, in the third year of kindergarten. Fitness tests included grip strength, standing long jump, and 25 m run. A multi-frequency composition analyzer was used for body composition analysis, and the phase angle of the left half of the body was acquired at 50 kHz. Statistical analysis was performed using a general linear model to calculate the regression coefficient of phase angle for physical fitness. Phase angle correlated significantly with the standing long jump and 25 m run. The regression coefficient (±standard error) of phase angle in the standing long jump in the fully adjusted model was 5.098 ±2.264 (p<0.05), and that in the 25 m run was -0.179 ±0.088 (p<0.05). There was no significant correlation between phase angle and grip strength. These results suggest that phase angle based on bioelectrical impedance analysis might be related to lower limb muscle function and running ability in 6-year-old Japanese children.

Analysis of the function orientation and social environment of medical institutions run by state-owned enterprises / 中华医院管理杂志

In order to give full play to the social functions of state-owned enterprises running medical institutions, find out the functional orientation, and maximize their role in the context of regional health planning, the author made a comprehensive analysis of the functional orientation of state-owned enterprises running medical institutions. It is suggested that governments at all levels should integrate the state-owned enterprise-run medical institutions into the regional medical and health service system for overall planning, provide reasonable support and compensation for the public welfare responsibilities and tasks undertaken by state-owned enterprise hospitals, provide policy space for their exploration and innovation, and support the collectivization development of state-owned enterprise-run hospitals.

Analysis on the effect of resource integration of medical institutions run by state-owned enterprises / 中华医院管理杂志

With the deepening reform of state-owned enterprise-run medical institutions, a large number of medical institutions have entered the state-owned enterprises dominated by the health industry through resource integration. The research team conducted in-depth research on six medical institutions run by state-owned enterprises and analyzed the effect of resource integration. The research found that the investment of the holding enterprises in hospitals was significantly increased, the talent team tended to be stable, and the scope and volume of medical services were improved, but there were still problems such as insufficient participation in market competition and large differences in hospital operation, which needed to be further explored in practice.

Strategic analysis of the development of medical institutions run by state-owned enterprises in China / 中华医院管理杂志

In order to adapt to the development of market economy, the original medical institutions run by state-owned enterprises have undergone restructuring reform, but these medical institutions have not fully played their role. Through the sampling survey and research interviews of several medical institutions run by state-owned enterprises, it was found that many problems such as unclear functional positioning, imperfect regional health planning, unclear responsible subjects and inadequate financial support hindered the development of medical institutions run by state-owned enterprises. In order to develop healthily, medical institutions run by state-owned enterprises need to cooperate with various parties to improve supporting policies, optimize their business environment, and build and improve the health service system.

Do restinga cnemidophorine lizards run on empty along the Brazilian coast? / Os lagartos cnemidophorine de restinga correm no vazio ao longo da costa brasileira?

Abstract The number of individuals with empty stomachs in a population (i.e. the proportion of individuals "running on empty") can be used as a simple index of instantaneous energy balance of some organisms such as lizards and fishes. In this study, we aimed to analyze the proportion of empty stomachs in 16 populations of five cnemidophorine species (Glaucomastix abaetensis, Ameivula ocellifera, Glaucomastix littoralis, Contomastix lacertoides and Ameivula nativo) along approximately 5,000 km the Brazilian coast. A total of 550 individuals had their stomach contents removed and identified in the laboratory. Our results showed that the proportion of individuals "running on empty" varied from 0 to 11.1% among the different populations and species. These proportions are suggestive that the five studied species would be in an overall positive energy balance at the time of the study.

Resumo O número de indivíduos com estômagos vazios em uma população (i.e. a proporção de indivíduos "correndo no vazio") pode ser usado como um índice simples do balanço energético instantâneo de organismos como lagartos e peixes. Este estudo teve como objetivo analisar a proporção de estômagos vazios em 16 populações pertencentes a cinco espécies de cnemidophorines (Glaucomastix abaetensis, Ameivula ocellifera, Glaucomastix littoralis, Contomastix lacertoides e Ameivula nativo) ao longo de cerca de 5,000 km da costa leste do Brasil. Um total de 550 indivíduos tiveram seus conteúdos estomacais removidos e analisados em laboratório. Nossos resultados mostraram que a proporção de indivíduos "correndo no vazio" variou entre 0 a 11.1% entre as diferentes populações e espécies. Essas proporções sugerem que as cinco espécies estudadas estariam em geral em um balanço energético positivo, quando da realização deste estudo.

Inhibitory Effect of Weichang'an Granule on Invasion and Metastasis of MKN45 Cells in Human Gastric Cancer by RUFY3 / 中国实验方剂学杂志

Objective:To explore the molecular mechanism of spleen-strengthening traditional Chinese medicine （TCM） Weichang'an granule in inhibiting the invasion and metastasis of human gastric cancer MKN45 cells. Method:MKN45 cells were cultured <italic>in vitro</italic> and incubated with different concentrations（600， 900， 1 200， 1 500 mg·L^-1）of Weichang'an granule for 24， 48， 72 h. Cell counting kit-8 （CCK-8） assay was used to detect its effect on the cell proliferation. Western blot was used to detect the expression of RUN and FYVE domain containing 3（RUFY3） in normal gastric mucosa cells and different gastric cancer cell lines. The expression of RUFY3 in the gastric cancer cells after Weichang'an granule intervention （600， 900， 1 200 mg·L^-1） was detected by Western blot. Lentivirus transfection technique was used to achieve the stable and silenced expression of RUFY3 in gastric cancer MKN45 cells. Transwell assay was used to evaluate the influence of Weichang'an granule and silenced RUFY3 on the metastasis and invasion ability of MKN45. E-cadherin，N-cadherin，Vimentin，Zinc-finger transcription factor （SNAIL1 and SNAIL2） protein expression levels were detected by Western blot. Result:RUFY3 expression in human gastric cancer cells was significantly higher than that in normal gastric mucosa．The protein expression of RUFY3 in MKN45 cells of silenced RUFY3 group was significantly lower than that in Lentivirus negative group （<italic>P</italic><0.01）． Weichang'an granule inhibited the expression of RUFY3 in human MKN45 gastric cancer cells （<italic>P</italic><0.05， <italic>P</italic><0.01） in a concentration-dependent manner. As compared with the blank group， both Weichang'an granule and silenced RUFY3 inhibited the metastasis and invasion ability of MKN45 （<italic>P</italic><0.01）. After Weichang'an granule and silenced RUFY3 treatment， the protein expression of epithelial marker gene E-cadherin was up-regulated （<italic>P</italic><0.01）， the protein expression of Vimentin and N-cadherin decreased， but with no statistical difference，while SNAIL1 and SNAIL2 were both significantly down-regulated （<italic>P</italic><0.01）. Conclusion:By targeting RUFY3 to regulate epithelial mesenchymal transformation， the spleen-strengthening TCM compound Weichang'an granule can inhibit the invasion and metastasis of gastric cancer.

Motivaciones para correr y el compromiso con el running en adultos argentinos de CABA y GBA / Motivations to running and commitment to running in argentinian adults

El presente estudio tuvo como objetivo describir el grado de motivación para correr y el compromiso con el running en adultos argentinos corredores de ambos sexos (53% masculino) de Ciudad Autónoma de Buenos Aires y Gran Buenos Aires analizar las relaciones entre las variables mencionadas y determinar cuáles de las motivaciones constituían los mayores predictores del compromiso para correr. A tal efecto se aplicaron las versiones en castellano de la MotivationsofMarathonersScale (Masters, Ogles&Jolton, 1993) y Commitmentto Running Scale(Carmack & Martens, 1979). Todos los participantes dieron su autorización para participar en el estudio. Los resultados evidenciaron niveles de compromiso con el running similar a estudios anteriores, y arrojaron una correlación positiva entre el compromiso a correr y todas las dimensiones de las motivaciones para correr, siendo las mayores la significación con la vida ­ autoestima y las metas personales - competencia. Además, estas dimensiones resultaron ser los mayores predictores del compromiso. Los resultados del presente estudio brindan un nuevo aporte a la promoción de la salud de las personas y los beneficios de la práctica deportiva.

The present study aimed to describe the levels of motivations to run and commitment to running in Argentine adult runners of both sexes (53% male) from CABA and GBA, analyse the relationships between the mentioned variables and determine which of the motivations were the main predictors of commitment to running. Therefore, the Spanish versions of the Motivations of Marathoners Scale (Masters, Ogles & Jolton, 1993) and the Commitment to Running Scale (Carmack & Martens, 1979) were applied. All participants agreed to participate in the study. The results pointed out levels of commitment to running similar to previous research, along with a positive correlation between commitment to running and all dimensions of motivations to run, reaching the highest score the significance with life - self-esteem and personal goals - competence. Furthermore, these dimensions turned out to be the main predictors of commitment. The results of this study provide a new contribution to promote people's health and the benefits of the sports practice

Successful xenotransfusion from a domestic dog (Canis familiaris) to an Andean fox (Lycalopex culpaeus) / Sucesso da xenotransfusão de um cão doméstico (Canis familiaris) para uma raposa andina (Lycalopex culpaeus)

An Andean fox was transferred to the Wildlife Hospital of the Universidad San Francisco de Quito for evaluation of injuries caused by a run over. Clinical signs of hypovolemic shock were detected. Radiographies showed multiple pelvic fractures and free fluid in retroperitoneal cavity. The presumptive diagnosis was hemorrhagic shock caused by blood loss secondary to a pelvis fracture. An emergency xenotransfusion using blood from a domestic dog was performed without acute transfusion reactions observed. This is the first report of successful xenotransfusion between a domestic dog and an Andean fox presenting a procedure that could be applied in emergency situations.(AU)

Uma raposa andina foi levada ao Hospital da Vida Selvagem da Universidad San Francisco de Quito para avaliar os ferimentos causados por um atropelamento. Sinais clínicos de choque hipovolêmico foram detectados. Radiografias mostraram múltiplas fraturas pélvicas e fluido livre na cavidade retroperitoneal. O diagnóstico presuntivo foi um choque hemorrágico causado por perda sanguínea secundária a uma fratura pélvica. Uma xenotransfusão de emergência foi realizada com o sangue de um cão doméstico sem reações agudas transfusionais. Este é o primeiro relato bem sucedido de xenotransfusão entre um cão doméstico e uma raposa andina, demonstrando que é um procedimento que poderá ser considerado em situações de emergência.(AU)

Prediction Equation For Shuttle Run Distance Using 20 Metre Shuttle Run Test In Healthy, Indian Children Aged 7 To 19 Years.

Background: Dental anxiety is a significant and challenging problem in patients seeking dental treatment. During any dental procedure patients often experience severe pre-operative and intra-operative anxiety which makes the procedure more difficult. Anxiety during endodontic therapy often leads to increased pain perceptions and instability of the physiological parameter throughout treatment. Aim: The purpose of this study was to evaluate the influence of music as a nonpharmacologic aid on anxiety, pain perception and physiological parameters (heart rate, systolic blood pressure, and diastolic blood pressure) at three different time period - before, during, and after endodontic treatment. Methods: A total of 100 patients were recruited in the present study. Before starting the endodontic treatment, the interviewer administered the Modified Corah Dental Anxiety Scale (MCDAS) to assess the baseline level of anxiety and Visual Analog Scale (VAS) for pain assessment. Patients were randomly divided into 2 groups: the first one listened to the music during endodontic treatment and the second one did not. Before, during, and after the endodontic procedure, the physiological parameters (i.e. heart rate, systolic and diastolic blood pressure) were recorded. All the data were collected and statistically analyzed. Results: Direct contrasts between patients listening or not listening to music showed that all the measured physiological parameters improved considering the overall period (during and after the root canal therapy) in the group of patients listening to music (P < .05). Conclusion: Within the limitation of the study, music administered to subjects with different levels of anxiety during endodontic treatment significantly decreased pain levels and improved physiological parameters during the endodontic procedures. Clinical Significance: Music and medicine always work together and the soothing effects of sounds and musical frequencies make this union an extraordinary tool of synergistic care. Music therapy can be considered as a valid nonpharmacologic aid to manage anxiety during endodontic treatment.

Comparison between incremental shuttle run test and Harvard’s step test on peak exercise performance in healthy males: a cross-sectional study

Background: Cardiovascular fitness is directly related to the physical health of the person. Aerobic capacity (VO2max) is one of the major criteria to decide the cardiovascular fitness of an individual. To help quantify the fitness level by calculating their VO2max, there are various indirect maximal tests available but out of these, which one would predict VO2max better, is a major concern. Hence the purpose of this study was to compare the effects of two indirect maximal tests i.e. Incremental Shuttle Run Test (ISRT) and Harvard’s Step Test (HST) on peak exercise performance in young healthy males.Methods: A cross-sectional study with purposive sampling was performed on healthy untrained 100 males of age group 18-25 years. Day 1 subjects performed ISRT on 20 m track and after a 48 hours rest period, on day 3 same subject performed Harvard’s step test. Pre and post-test parameters (Pulse rate, respiratory rate, systolic and diastolic blood pressure and RPE) were measured and predicted VO2max was calculated.Results: Post-test parameters i.e. PR, RR, SBP significantly increased (p=0.00*) by Harvard’s step test. The diastolic blood pressure did not change significantly (p=0.3) for both the tests. Rating of perceived exertion by both the test was of the range 17-19 (very hard to maximal). Calculated predicted VO2max was significantly more by ISRT than HST in males (p=0.00*).Conclusions: Incremental shuttle run test is more efficient in predicting VO2max than Harvard’s step test in healthy adult’s males.

Health-related physical fitness and weight status in 13- to 15-year-old Latino adolescents. A pooled analysis / Aptidão física relacionada à saúde e status do peso em adolescentes latinos de 13 a 15 anos de idade. Uma análise em conjunto

Abstract Objective: The aim of this study was to investigate the relation between health-related physical fitness and weight status in 13- to 15-year-old Latino adolescents. Method: The final sample consisted of 73,561 adolescents aged 13 -15 years (35,175 girls) from Chile (n = 48,771) and Colombia (n = 24,790). Cardiorespiratory and musculoskeletal fitness were measured using 20-m shuttle run (relative peak oxygen uptake - VO2peak) and standing broad jump test (lower body explosive strength), respectively. The International Obesity Task Force definition was used to define weight status (i.e., underweight, normal weight, overweight, and obese). Results: The present study found an inverted J-shape relationship between body mass index, cardiorespiratory fitness, and musculoskeletal fitness in both genders and all age groups (p < 0.01). Results also suggest that underweight adolescents, and not just overweight and obese adolescents, have lower odds of having a healthy cardiorespiratory fitness (based on new international criterion-referenced standards) profile when compared with their normal weight peers, except in girls aged 14 (p = 0.268) and 15 years (p = 0.280). Conclusions: The present results indicate low cardiorespiratory fitness and musculoskeletal fitness levels in underweight, overweight, and obese adolescents when compared with their normal weight peers. The findings appear to suggest that exercise programs should to decrease fat mass in overweight/obese adolescents and increase muscle mass in underweight adolescents.

Resumo Objetivo: Investigar a relação entre a aptidão física relacionada à saúde e o status do peso em adolescentes latinos de 13 a 15 anos. Método: A amostra final consistiu em 73.561 adolescentes entre 13 e 15 anos (35.175 meninas) do Chile (n = 48.771) e da Colômbia (n = 24.790). As aptidões cardiorrespiratória e musculoesquelética foram medidas com a corrida vaivém de 20 m (consumo máximo de oxigênio relativo - VO2máx.) e o teste de impulso horizontal (menor força explosiva do corpo), respectivamente. A definição Força-Tarefa Internacional de Obesidade foi usada para definir o status do peso (ou seja, abaixo do peso, peso normal, sobrepeso e obeso). Resultados: O presente estudo encontrou uma relação na forma de J invertido entre o índice de massa corporal, a aptidão cardiorrespiratória e a aptidão musculoesquelética em ambos os sexos e em todas as faixas etárias (p < 0,01). Os resultados também sugerem que os adolescentes abaixo do peso e não somente os adolescentes acima do peso e obesos têm menor chance de ter um perfil de aptidão cardiorrespiratória saudável (com base em novos padrões internacionais referenciados a critério) em comparação com os pares com peso normal, exceto em meninas de 14 (p = 0,268) e 15 anos (p = 0,280). Conclusões: Nossos resultados mostram baixos níveis de aptidão cardiorrespiratória e aptidão musculoesquelética em adolescentes abaixo do peso, acima do peso e obesos em comparação com os pares com peso normal. Os achados parecem sugerir que os programas de exercícios devam ser voltados para reduzir a massa gorda em adolescentes com sobrepeso/obesos e aumentar a massa muscular em adolescentes abaixo do peso.

Programa de ejercicios con bandas elásticas de resistencia para el incremento de la velocidad en la carrera home-primera base, con jugadores de béisbol, categoría juvenil de Matanzas / Program of exercises with elastic resistance bands for the increase of the speed in the home-first base race with junior baseball players from Matanzas

RESUMEN En las últimas décadas, se han incorporado a los programas de entrenamiento ejercicios con la utilización de tubos (redondos) o bandas (planas) elásticas, de resistencia progresiva, lo que constituye una herramienta fundamental para desarrollar la fuerza muscular e imitar movimientos o gestos deportivos en numerosas especialidades deportivas, debido a su facilidad de uso. El objetivo del presente estudio fue diseñar un programa de entrenamiento con bandas elásticas de resistencia para el incremento de la velocidad, en la carrera home-primera base, con jugadores de la categoría juvenil de Matanzas que participaron en el XLVI Campeonato Nacional de Béisbol. La etapa experimental se desarrolla durante el periodo preparatorio, que constó de 20 microciclos de duración, con una frecuencia de tres días por semana, utilizando la combinación de ejercicios de velocidad con bandas o tubos elásticos y los modelos de periodización de la fuerza y el Sistema de Bloque o Fuerza Concentrada. Los resultados demuestran cambios significativos en los tiempos de la carrera home-primera base de los jugadores, en los diferentes controles efectuados para un 95 % de confianza, pues el valor de la probabilidad (p-value=0.0001) es menor que 0.05. Además, se alcanza un 4.37 % de incremento, con una reducción de los tiempos de 0.37 segundos.

ABSTRACT In the last decades, exercises with the use of tubes (round) or elastic bands (flat) of progressive resistance have been incorporated into the training programs, being a fundamental tool to develop muscle strength and imitate sport movements or gestures in numerous sports specialties, because of its ease to be used. The objective of this study was to design a training program with elastic resistance bands for the increase of the speed in the home-first base race with junior baseball players from Matanzas who participated in the XLVI National Baseball Championship. The experimental stage is developed during the preparatory period, which had a duration of 20 micro cycles, with a frequency of three days per week, using the combination of speed exercises with bands or elastic tubes and the models of periodization of strength and the System of Block or Concentrated Strength. The results show significant changes in the times of the home-first base race of the players in the different controls carried out with a 95% of confidence, since the value of the probability (p-value=0.0001) is less than 0.05. In addition, a 4.37 % increase was achieved with a reduction of 0.37 seconds.

Dummy Run of Quality Assurance Program before Prospective Study of Hippocampus-Sparing Whole-Brain Radiotherapy and Simultaneous Integrated Boost for Multiple Brain Metastases from Non-small Cell Lung Cancer: Korean Radiation Oncology Group (KROG) 17-06 Study / Journal of the Korean Cancer Association, 대한암학회지

PURPOSE: Lung Cancer Subcommittee of Korean Radiation Oncology Group (KROG) has recently launched a prospective clinical trial (KROG 17-06) of hippocampus-sparing whole brain radiotherapy (HS-WBRT) with simultaneous integrated boost (SIB) in treating multiple brain metastases from non-small cell lung cancer. In order to improve trial quality, dummy run studies among the participating institutions were designed. This work reported the results of two-step dummy run procedures of the KROG 17-06 study. MATERIALS AND METHODS: Two steps tested hippocampus contouring variability and radiation therapy planning compliance. In the first step, the variation of the hippocampus delineation was investigated for two representative cases using the Dice similarity coefficients. In the second step, the participating institutions were requested to generate a HS-WBRT with SIB treatment plan for another representative case. The compliance of the treatment plans to the planning protocol was evaluated. RESULTS: In the first step, the median Dice similarity coefficients of the hippocampus contours for two other dummy run cases changed from 0.669 (range, 0.073 to 0.712) to 0.690 (range, 0.522 to 0.750) and from 0.291 (range, 0.219 to 0.522) to 0.412 (range, 0.264 to 0.598) after providing the hippocampus contouring feedback. In the second step, with providing additional plan priority and extended dose constraints to the target volumes and normal structures, we observed the improved compliance of the treatment plans to the planning protocol. CONCLUSION: The dummy run studies demonstrated the notable inter-institutional variability in delineating the hippocampus and treatment plan generation, which could be decreased through feedback from the trial center.

Inhibition Effect of Weichang'an Granule and Decoction on Tumor Growth and Lymph Node Metastasis by RUFY3, SNAI1, VEGF, EMT Related Proteins in Nude Mice with Subcutaneous Xenograft Tumor of Human Gastric Carcinoma MKN45 / 中国实验方剂学杂志

Objective: To observe the effect of Weichang'an on the tumor growth and lymph node metastasis, and RUN and FYVE domain-containing protein 3(RUFY3),Zinc finger protein 1(SNAI1),vascular endothelial growth factor(VEGF),epithelial-mesenchymal transition(EMT)-related proteins in nude mice with subcutaneous xenograft tumor human gastric carcinoma MKN45, so as to discuss the mechanism of Weichang'an on MKN45 human gastric metastasis. Method: The nude mice model of human gastric carcinoma MKN45 cells was established and randomly divided into normal saline group (0.5 mL/mouse), Weichang'an granule group (3.54 g·kg-1) and Weichang'an decoction group (35.49 g·kg-1). The tumor weight and volume of axillary lymph nodes in each group were observed. The morphology of lymph nodes in each group was detected by hematoxylin-eosin (HE) staining. The expressions of related proteins were detected by immunohistochemistry, including RUFY3,SNAI1,VEGF,E-cadherin,N-cadherin,Vimentin. Result: Compared with the normal saline group, the tumor weight and volume of axillary lymph node were decreased (PPPConclusion: Both Weichang'an granule and Weichang'an decoction can inhibit the tumor growth and metastasis of axillary lymph nodes, obviously down-regulate the expressions of RUFY3,SNAI1,VEGF,N-cadherin,Vimentin and up-regulate the expression of E-cadherin in human gastric MKN45 subcutaneous transplanted tumor in nude mice. This suggested that Weichang'an may inhibit the tumor metastasis through regulation expressions of RUFY3,SNAI1,VEGF and EMT-related proteins.

A Novel Run-length based wavelet features for Screening Thyroid Nodule Malignancy

Abstract: Thyroid nodules are cell growths in the thyroid which might be for in one of two categories benign or malignant. Nodular thyroid disease is common and because of the associated risk of malignancy and hyper-function; these nodules have to be examined thoroughly. Hence diagnosing thyroid nodule malignancy in the early stage can mitigate the possibility of death. This paper presents an intelligent thyroid nodules malignancy diagnosis using texture information in run-length matrix derived from 2- level 2D wavelet transform bands (approximation and details). In this work, ANOVA test has been used to for feature selection to reduce for feature selection about 45 run-length features with and without wavelet generated, before feeding those features which clinical importance to the Support Vector Machine(SVM) and Decision Tree (DT) classifier to perform the automated diagnosis. The validation of this work is activated using 100-thyroid nodule images spliced equally between the two categories (50 Benign and 50 Malignant). The proposed system can detect thyroid nodules malignancy with an average accuracy of about 97% using SVM classifier for the run- length matrix, features derived from spatial domain while the average accuracy is increased to 98% in case of hybrid feature derived from spatial domain and 2-level wavelet decomposition. For the other proposed classifier (DT), the average accuracy in case of spatial domain based features is 93% whereas the average accuracy of the hybrid features system is 97%. Hence the proposed system can be used for the screening of thyroid nodules.